Article
Differential binding of proteins to the IL1B -31 T/C polymorphism in lung epithelial cells.
Cytokine - 1 Apr 2007
Lind Helge, Haugen Aage, Zienolddiny Shanbeh
Abstract excerpt
Chronic inflammation has been implicated as a cofactor in the development of several human cancers. Interleukin-1beta is a key pro-inflammatory cytokine. We have previously shown associations between polymorphisms at position -511 and -31 in the promoter of the IL1B gene and risk of non-small cell lung cancer. In this study we investigated the functional role of the -31 T/C SNP in the regulation of the IL1B gene....
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