Independent Promoters Regulate the Expression of Two Amino Terminally Distinct Forms of Latent Transforming Growth Factor-β Binding Protein-1 (LTBP-1) in a Cell Type-specific Manner

Abstract excerpt

Latent transforming growth factor-beta (TGF-beta)-binding proteins (LTBPs) are components of the extracellular matrix and large latent TGF-beta complexes are secreted by various cells. Human LTBP-1 is known to exist in different forms. LTBP-1L (long) has an amino-terminal extension, which is not found in the smaller LTBP-1S isoform. To study the formation and transcriptional regulation of LTBP-1S and LTBP-1L...

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