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Article

Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering.

Molecular biology of the cell - 1 Aug 2000

Kodama A, Matozaki T, Fukuhara A, Kikyo M, Ichihashi M, Takai Y

Abstract excerpt

Hepatocyte growth factor/scatter factor (HGF/SF) induces cell scattering through the tyrosine kinase-type HGF/SF receptor c-Met. We have previously shown that Rho small G protein (Rho) is involved in the HGF/SF-induced scattering of Madin-Darby canine kidney (MDCK) cells by regulating at least the assembly and disassembly of stress fibers and focal adhesions, but it remains unknown how c-Met regulates Rho...

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Identifiers

PMID: 10930454
DOI: 10.1091/mbc.11.8.2565
PMCID: PMC14940

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering.PMID 10930454Read ↗

Regulation of Ras and Rho small G proteins by SHP-2.Semantic proximity Read ↗

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Semantic proximity Read ↗

Cellular contractility changes are sufficient to drive epithelial scattering.Semantic proximity Read ↗

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Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion.Semantic proximity Read ↗

JAM4 enhances hepatocyte growth factor-mediated branching and scattering of Madin-Darby canine kidney cells.Semantic proximity Read ↗

Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts.Semantic proximity Read ↗

Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis.Semantic proximity Read ↗

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The SH2-containing inositol 5-phosphatase (SHIP)-1 is implicated in the control of cell-cell junction and induces dissociation and dispersion of MDCK cells.Semantic proximity Read ↗

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