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Article

Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts.

Cellular signalling - 1 Nov 2006

Duan Hai-Feng, Qu Cheng-Kui, Zhang Qun-Wei, Yu Wen-Mei, Wang Hong, Wu Chu-Tse, Wang Li-Sheng

Abstract excerpt

Shp-2, a ubiquitously expressed protein tyrosine phosphatase containing two Src homology 2 domains, plays an important role in integrating signaling from the cell surface receptors to intracellular signaling mechanisms. Previous studies have demonstrated that the Shp-2 is involved in hepatocyte growth factor (HGF)-induced cell scattering. Here we report that Shp-2 is required for the HGF-induced activation of...

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Source

Identifiers

PMID: 16765027
DOI: 10.1016/j.cellsig.2006.04.002

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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