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Article

Regulation of Ras and Rho small G proteins by SHP-2.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2001

Kodama A, Matozaki T, Shinohara M, Fukuhara A, Tachibana K, Ichihashi M, Nakanishi H, Takai Y

Abstract excerpt

BACKGROUND: Hepatocyte growth factor/scatter factor (HGF/SF) induces cell scattering through the tyrosine kinase-type HGF/SF receptor, c-Met. We have previously shown that SHP-2, a protein tyrosine phosphatase, positively regulates the HGF/SF-induced cell scattering through modulating the activity of Rho to form stress fibres and focal adhesions. To further investigate the role of SHP-2 in HGF/SF-induced cell...

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Source

Identifiers

PMID: 11683915
DOI: 10.1046/j.1365-2443.2001.00467.x

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of Ras and Rho small G proteins by SHP-2.PMID 11683915Read ↗

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