Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis.

Journal of cellular physiology - 1 Nov 1997

Royal I, Fournier T M, Park M

Abstract excerpt

Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional cytokine that induces mitogenesis, motility, invasion, and morphogenesis of several epithelial and endothelial cell lines in culture. The receptor for HGF/SF has been identified as the Met tyrosine kinase. To investigate the signaling pathways that are involved in these events, we have generated chimeric receptors containing the extracellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Cell Movement
Share to Chimera

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kidney

Share to Mutation

Share to Phosphatidylinositol 3-Kinases

Share to Proteins

Source

Identifiers

PMID: 9365521
DOI: 10.1002/(SICI)1097-4652(199711)173:2<196::AID-JCP20>3.0.CO;2-D

Genes

HGF
MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis.PMID 9365521Read ↗

The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review).Semantic proximity Read ↗

C-Met signalling in an HGF/SF-insensitive variant MDCK cell line with constitutive motile/invasive behaviour.Semantic proximity Read ↗

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.Semantic proximity Read ↗

Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.Semantic proximity Read ↗

Hepatocyte growth factor/scatter factor-induced intracellular signalling.Semantic proximity Read ↗

The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair.Semantic proximity Read ↗

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Semantic proximity Read ↗

HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity.Semantic proximity Read ↗

JAM4 enhances hepatocyte growth factor-mediated branching and scattering of Madin-Darby canine kidney cells.Semantic proximity Read ↗

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.Semantic proximity Read ↗

The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering.Semantic proximity Read ↗

A scatter factor-like factor is produced by a metastatic variant of a rat bladder carcinoma cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.