Article
Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis.
Journal of cellular physiology - 1 Nov 1997
Royal I, Fournier T M, Park M
Abstract excerpt
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional cytokine that induces mitogenesis, motility, invasion, and morphogenesis of several epithelial and endothelial cell lines in culture. The receptor for HGF/SF has been identified as the Met tyrosine kinase. To investigate the si...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Cell Movement
- Chimera
- Colony-Stimulating Factors
- Dogs
- GRB2 Adaptor Protein
- Hepatocyte Growth Factor
- Kidney
- Mutation
- Phosphatidylinositol 3-Kinases
- Proteins
- Proto-Oncogene Proteins c-met
- Receptors, Colony-Stimulating Factor
- Tight Junctions