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Article

LIN-39/Hox triggers cell division and represses EFF-1/fusogen-dependent vulval cell fusion.

Genes & development - 15 Dec 2002

Shemer Gidi, Podbilewicz Benjamin

Abstract excerpt

General mechanisms by which Hox genes establish cell fates are known. However, a few Hox effectors mediating cell behaviors have been identified. Here we found the first effector of LIN-39/HoxD4/Dfd in Caenorhabditis elegans. In specific vulval precursor cells (VPCs), LIN-39 represses early and late expression of EFF-1, a membrane protein essential for cell fusion. Repression of eff-1 is also achieved by the...

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Identifiers

PMID: 12502736
DOI: 10.1101/gad.251202
PMCID: PMC187502

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LIN-39/Hox triggers cell division and represses EFF-1/fusogen-dependent vulval cell fusion.PMID 12502736Read ↗

Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein.Semantic proximity Read ↗

Role of C. elegans lin-40 MTA in vulval fate specification and morphogenesis.Semantic proximity Read ↗

AFF-1, a FOS-1-regulated fusogen, mediates fusion of the anchor cell in C. elegans.Semantic proximity Read ↗

The type I membrane protein EFF-1 is essential for developmental cell fusion.Semantic proximity Read ↗

REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity.Semantic proximity Read ↗

The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling.Semantic proximity Read ↗

The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.Semantic proximity Read ↗

Fusogenic activity of EFF-1 is regulated via dynamic localization in fusing somatic cells of C. elegans.Semantic proximity Read ↗

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sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

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