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The many faces of the helicase RTEL1 at telomeres and beyond.

Trends in cell biology - 1 Feb 2024

Hourvitz Noa, Awad Aya, Tzfati Yehuda

Abstract excerpt

Regulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction, the wide spectrum of symptoms caused by germline RTEL1 mutations, and the association of RTEL1 mutations with cancers suggest that RTEL1 is a complex machine that interacts with DNA, RNA, and proteins, and functions in diverse cellular...

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PMID: 37532653
DOI: 10.1016/j.tcb.2023.07.002

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The many faces of the helicase RTEL1 at telomeres and beyond.PMID 37532653Read ↗

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Structural Motifs at the Telomeres and Their Role in Regulatory PathwaysSemantic proximity Read ↗

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