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Article

Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2009

Oze Isao, Matsuo Keitaro, Suzuki Takeshi, Kawase Takakazu, Watanabe Miki, Hiraki Akio, Ito Hidemi, Hosono Satoyo, Ozawa Taijiro, Hatooka Shunzo, Yatabe Yasuhi, Hasegawa Yasuhisa, Shinoda Masayuki, Kiura Katsuyuki, Tajima Kazuo, Tanimoto Mitsune, Tanaka Hideo

Abstract excerpt

Alcohol intake is positively associated with the risk of upper aerodigestive tract (UAT) cancer. The genes that encode alcohol-metabolizing enzymes, primarily alcohol dehydrogenases (ADH) and aldehyde dehydrogenases (ALDH), are polymorphic. In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage...

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Source

Identifiers

PMID: 19861527
DOI: 10.1158/1055-9965.EPI-09-0499

Genes

ADH4
ADH7
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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