Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth.

doi:10.1093/jnci/87.19.1478

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Article

Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth.

Journal of the National Cancer Institute - 4 Oct 1995

Ghosh P, Komschlies K L, Cippitelli M, Longo D L, Subleski J, Ye J, Sica A, Young H A, Wiltrout R H, Ochoa A C

Abstract excerpt

BACKGROUND: The carefully orchestrated events that result in a protective immune response are coordinated to a large extent by cytokines produced by T helper 1 (Th1) and T helper 2 (Th2) T-cell subsets, which are two arms of the immune system. Th1 cells preferentially produce interleukin 2 (IL-2), interferon gamma (IFN gamma), and tumor necrosis factor (TNF), resulting in a cellular response that helps to...

Topics

Animals
Base Sequence
Carcinoma, Renal Cell
Colonic Neoplasms
DNA, Neoplasm
Disease Progression
Electrophoresis
Immunoglobulin kappa-Chains
Interferon-gamma
Interleukin-2
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphokines

Mice

Molecular Sequence Data

Neoplasms, Experimental

Phenotype

Spleen

T-Lymphocyte Subsets

Source

Open in PubMed

Identifiers

PMID: 7674335
DOI: 10.1093/jnci/87.19.1478

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7674335-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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