Article
Detection of single cells secreting IFN-gamma, IL-6, and IL-10 in irreversibly rejected human kidney allografts, and their modulation by IL-2 and IL-4.
Transplantation - 1 Mar 1993
Merville P, Pouteil-Noble C, Wijdenes J, Potaux L, Touraine J L, Banchereau J
Abstract excerpt
The frequency of isolated low-density graft-infiltrating cells (GIC) secreting IFN-gamma, IL-6, and IL-10 was studied in 8 cases of irreversible rejection of human renal allografts, using ELISA and SPOT-forming cells (ELISPOT) assays. The GIC were mostly CD8+ T cells, although CD4+ T cells, B cel...
Topics
- Adjuvants, Immunologic
- Antigen-Presenting Cells
- Cytokines
- Enzyme-Linked Immunosorbent Assay
- Graft Rejection
- Humans
- Interferon-gamma
- Interleukin-10
- Interleukin-2
- Interleukin-4
- Interleukin-6
- Kidney Transplantation
- Killer Cells, Natural
- Monocytes
- Phenotype
- Transplantation, Homologous