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Article

Characterization of human pre-elafin mutants: full antipeptidase activity is essential to preserve lung tissue integrity in experimental emphysema.

The Biochemical journal - 1 Aug 2007

Doucet Alain, Bouchard Dominique, Janelle Marie France, Bellemare Audrey, Gagné Stéphane, Tremblay Guy M, Bourbonnais Yves

Abstract excerpt

Pre-elafin is a tight-binding inhibitor of neutrophil elastase and myeloblastin; two enzymes thought to contribute to tissue damage in lung emphysema. Previous studies have established that pre-elafin is also an effective anti-inflammatory molecule. However, it is not clear whether both functions are linked to the antipeptidase activity of pre-elafin. As a first step toward elucidating the structure/function...

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Identifiers

PMID: 17489739
DOI: 10.1042/BJ20070020
PMCID: PMC2267300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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