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Article

Mechanisms of serpin dysfunction in disease.

Expert reviews in molecular medicine - 11 Dec 2006

Kaiserman Dion, Whisstock James C, Bird Phillip I

Abstract excerpt

The serpin superfamily encompasses hundreds of proteins, spread across all kingdoms of life, linked by a common tertiary fold. This review focuses on five diseases caused by serpin dysfunction: variants of antithrombin III lose their ability to interact with heparin; the alpha1-antitrypsin Pittsburgh mutation causes a change in target proteinase; the alpha1-antitrypsin Z mutation and neuroserpin, polymerisation...

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Identifiers

PMID: 17156576
DOI: 10.1017/S1462399406000184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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