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Article

A structure-function study of a proton transport pathway in the gamma-class carbonic anhydrase from Methanosarcina thermophila.

Biochemistry - 8 Aug 2000

Tripp B C, Ferry J G

Abstract excerpt

Four glutamate residues in the prototypic gamma-class carbonic anhydrase from Methanosarcina thermophila (Cam) were characterized by site-directed mutagenesis and chemical rescue studies. Alanine substitution indicated that an external loop residue, Glu 84, and an internal active site residue, Glu 62, are both important for CO(2) hydration activity. Two other external loop residues, Glu 88 and Glu 89, are less...

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PMID: 10924116
DOI: 10.1021/bi0001877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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