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Article

Evidence for a bicarbonate "escort" site in Haemophilus influenzae beta-carbonic anhydrase .

Biochemistry - 4 May 2010

Rowlett Roger S, Hoffmann Katherine M, Failing Hannah, Mysliwiec Margaret M, Samardzic Dejan

Abstract excerpt

The Haemophilus influenzae beta-carbonic anhydrase (HICA) allosteric site variants V47A and G41A were overexpressed and purified to homogeneity. These variants have k(cat)/K(m) values similar to that of the wild-type enzyme and exhibit a similar dramatic decrease in catalytic activity at pH <8.0. However, both HICA-G41A and -V47A were serendipitously found to bind sulfate ion or bicarbonate ion near pairs of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20359198
DOI: 10.1021/bi100328j
PMCID: PMC2861718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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