Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis

8 May 2025

Abstract excerpt

Complement activation is a relevant driver in the pathomechanisms of vasculitis. The involved proteins in the interaction between endothelia, complement, and platelets in these conditions are only partially understood. Thrombospondin-1 (TSP-1), found in platelet α-granules and released from activated endothelial cells, interacts with factor H (FH) and vWF. However, to our knowledge, direct regulatory interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Platelet Disorders and Treatments
Share to Vasculitis and related conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40338657
DOI: 10.1172/jci180062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitisPMID 40338657Read ↗

The role of von Willebrand factor in thrombotic microangiopathy.Semantic proximity Read ↗

Complement Mediated Endothelial Damage in Thrombotic MicroangiopathiesSemantic proximity Read ↗

Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panaceaSemantic proximity Read ↗

Endothelial cells: source, barrier, and target of defensive mediatorsSemantic proximity Read ↗

The complement alternative pathway and hemostasisSemantic proximity Read ↗

C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patientsSemantic proximity Read ↗

Overall Neutralization of Complement Factor H by Autoantibodies in the Acute Phase of the Autoimmune Form of Atypical Hemolytic Uremic SyndromeSemantic proximity Read ↗

Thrombotic microangiopathy without renal involvement: two novel mutations in complement-regulator genes.Semantic proximity Read ↗

The molecular mechanism of thrombospondin family members in cardiovascular diseasesSemantic proximity Read ↗

Interaction between the metalloprotease ADAMTS-13 and the proteins of the alternative pathway of the complement systemSemantic proximity Read ↗

Complement activation in diseases presenting with thrombotic microangiopathy.Semantic proximity Read ↗

Potential influences of complement factor H in autoimmune inflammatory and thrombotic disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.