Article
Antibodies against TFPI and protein C are associated with a severe thrombotic phenotype in patients with and without antiphospholipid syndrome.
Thrombosis research - 1 Oct 2018
Efthymiou M, Arachchillage D R J, Lane P J, O'Keeffe A G, McDonnell T, Cohen H, Mackie I J
Abstract excerpt
BACKGROUND: Tissue factor pathway inhibitor (TFPI) antibodies, which have been reported in patients with antiphospholipid syndrome (APS), may impair TFPI activity and contribute to hypercoagulability, but their role in APS and in thrombosis remains undefined. OBJECTIVE/METHODS: We assessed the presence and avidity of TFPI IgG antibodies, associations with protein C IgG antibodies and associations with clinical...
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