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Article

A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide.

Archives of general psychiatry - 1 Aug 2000

Mann J J, Huang Y Y, Underwood M D, Kassir S A, Oppenheim S, Kelly T M, Dwork A J, Arango V

Abstract excerpt

BACKGROUND: Major depression and suicide are associated with fewer serotonin transporter (5-HTT) sites. The 5'-flanking promoter region of the 5-HTT gene has a biallelic insertion/deletion (5-HTTLPR). We assayed prefrontal cortical (PFC) 5-HTT binding in major depression and suicide and examine the relationship to the 5-HTTLPR allele. METHODS: Postmortem brain samples from 220 individuals were genotyped for the...

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Source

Identifiers

PMID: 10920459
DOI: 10.1001/archpsyc.57.8.729

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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