Article
Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 1999
Huang Y Y, Grailhe R, Arango V, Hen R, Mann J J
Abstract excerpt
Knockout of the 5-HT1B gene in mice results in increased aggression, as well as alcohol and cocaine consumption. Given the clinical association of aggression, suicide, alcoholism, and substance abuse, we studied relationship of psychopathology to the human 5-HT1B receptor gene (N = 178) and postmortem human 5-HT1B receptor binding (N = 96) in the brain. The sample comprised: 71 suicide victims, 107 nonsuicides,...
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