TGF‐β regulation of epithelial cell proliferation

Abstract excerpt

Abstract The predominant effect of TGF‐β1 on cell proliferation is inhibition. Earlier studies demonstrated that TGF‐β1 inhibition of skin keratinocyte proliferation involves suppression of c‐ myc transcription and indirect evidence suggested that the protein product of the retinoblastoma gene (pRB) may be involved in this process. Skin keratinocytes transformed by SV40 and human papilloma virus‐16 (HPV‐16) or...

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