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Article

AP4 encodes a c-MYC-inducible repressor of <i>p21</i>

25 Sept 2008

Abstract excerpt

In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. Induction of AP4 was required for c-MYC-mediated cell cycle reentry of anti-estrogen arrested breast cancer cells and mitogen-mediated repression of the CDK inhibitor p21. AP4 directly repressed p21 by...

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PMID: 18818310
DOI: 10.1073/pnas.0801773105

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