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Article

Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers.

British journal of cancer - 21 Aug 2006

Clarke C L, Sandle J, Jones A A, Sofronis A, Patani N R, Lakhani S R

Abstract excerpt

We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, whether or not a tumour was present. Topographical mapping revealed that the genetic changes were...

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Source

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Identifiers

PMID: 16880780
DOI: 10.1038/sj.bjc.6603298
PMCID: PMC2360661

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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