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Assessment of normal and mutant human presenilin function in <i>Caenorhabditis elegans</i>

10 Dec 1996

Abstract excerpt

We provide evidence that normal human presenilins can substitute for Caenorhabditis elegans SEL-12 protein in functional assays in vivo. In addition, six familial Alzheimer disease-linked mutant human presenilins were tested and found to have reduced ability to rescue the sel-12 mutant phenotype, suggesting that they have lower than normal presenilin activity. A human presenilin 1 deletion variant that fails to...

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PMID: 8962160
DOI: 10.1073/pnas.93.25.14940

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Assessment of normal and mutant human presenilin function in <i>Caenorhabditis elegans</i>PMID 8962160Read ↗

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