Article
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998
Wu G, Hubbard E J, Kitajewski J K, Greenwald I
Abstract excerpt
Mutations in either of two human presenilin genes (PS1 and PS2) cause Alzheimer's disease. Here we describe genetic and physical interactions between Caenorhabditis elegans SEL-10, a member of the Cdc4p family of proteins, and SEL-12, a C. elegans presenilin. We show that loss of sel-10 activity...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Cycle Proteins
- Cell Line
- F-Box Proteins
- F-Box-WD Repeat-Containing Protein 7
- Genotype
- Helminth Proteins
- Humans
- Membrane Proteins
- Recombinant Proteins
- Transfection
- Ubiquitin-Protein Ligases