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Article

Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998

Wu G, Hubbard E J, Kitajewski J K, Greenwald I

Abstract excerpt

Mutations in either of two human presenilin genes (PS1 and PS2) cause Alzheimer's disease. Here we describe genetic and physical interactions between Caenorhabditis elegans SEL-10, a member of the Cdc4p family of proteins, and SEL-12, a C. elegans presenilin. We show that loss of sel-10 activity can suppress the egg-laying defective phenotype associated with reducing sel-12 activity, and that SEL-10 can...

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Identifiers

PMID: 9861048
DOI: 10.1073/pnas.95.26.15787
PMCID: PMC28122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.PMID 9861048Read ↗

SEL‐10 interacts with presenilin 1, facilitates its ubiquitination, and alters A‐beta peptide productionSemantic proximity Read ↗

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.Semantic proximity Read ↗

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.Semantic proximity Read ↗

The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.Semantic proximity Read ↗

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.Semantic proximity Read ↗

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.Semantic proximity Read ↗

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling.Semantic proximity Read ↗

Assessment of normal and mutant human presenilin function in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.Semantic proximity Read ↗

The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate.Semantic proximity Read ↗

Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.Semantic proximity Read ↗

Isolation and characterization of Drosophila presenilin homologSemantic proximity Read ↗

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