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Article

Activin βC and βE Genes Are Not Essential for Mouse Liver Growth, Differentiation, and Regeneration

1 Aug 2000

Abstract excerpt

The liver is an essential organ that produces several serum proteins, stores vital nutrients, and detoxifies many carcinogenic and xenobiotic compounds. Various growth factors positively regulate liver growth, but only a few negative regulators are known. Among the latter are the transforming growth factor beta (TGF-beta) superfamily members TGF-beta1 and activin A. To study the function of novel activin family...

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PMID: 10913194
DOI: 10.1128/mcb.20.16.6127-6137.2000

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Related research

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Research trail→

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Activin βC and βE Genes Are Not Essential for Mouse Liver Growth, Differentiation, and RegenerationPMID 10913194Read ↗

Overexpression of Activin βC or Activin βE in the Mouse Liver Inhibits Regenerative Deoxyribonucleic Acid Synthesis of Hepatic CellsSemantic proximity Read ↗

Conditional deletion of beta-catenin reveals its role in liver growth and regeneration.Semantic proximity Read ↗

Activin A is a prominent autocrine regulator of hepatocyte growth arrestSemantic proximity Read ↗

Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit.Semantic proximity Read ↗

Suppression of C/EBP α expression in biliary cell differentiation from hepatoblasts during mouse liver developmentSemantic proximity Read ↗

Activins Are Critical Modulators of Growth and SurvivalSemantic proximity Read ↗

Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration.Semantic proximity Read ↗

Functional analysis of activins during mammalian development.Semantic proximity Read ↗

Mice homozygous for a null mutation of activin beta B are viable and fertile.Semantic proximity Read ↗

Localization of Activin β<sub>A</sub>-,β<sub>B</sub>-, andβ<sub>C</sub>-Subunits in Human Prostate and Evidence for Formation of New Activin Heterodimers ofβ<sub>C</sub>-Subunit<sup>1</sup>Semantic proximity Read ↗

Liver regeneration and hepatocarcinogenesis in transforming growth factor-α-targeted miceSemantic proximity Read ↗

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