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Article

Functional analysis of activins during mammalian development.

Nature - 23 Mar 1995

Matzuk M M, Kumar T R, Vassalli A, Bickenbach J R, Roop D R, Jaenisch R, Bradley A

Abstract excerpt

Activins are dimeric (beta A beta A; beta B beta B; beta A beta B) members of the transforming growth factor-beta superfamily. They are widely expressed during murine development, are highly conserved during vertebrate evolution, and may be involved in mesoderm induction and neurulation in Xenopu...

Topics

Activins
Animals
Cell Line
Embryonic and Fetal Development
Growth Substances
Inhibins
Mice
Mice, Inbred C57BL
Mutation
Palate
Skull
Transforming Growth Factor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7885473
DOI: 10.1038/374354a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7885473-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Functional analysis of activins during mammalian development.PMID 7885473Read ↗

Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.Semantic proximity Read ↗

Role of the retinoic acid receptor beta (RARbeta) during mouse developmentSemantic proximity Read ↗

Activins Are Critical Modulators of Growth and SurvivalSemantic proximity Read ↗

Different phenotypes for mice deficient in either activins or activin receptor type II.Semantic proximity Read ↗

Mice homozygous for a null mutation of activin beta B are viable and fertile.Semantic proximity Read ↗

Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell InvasionSemantic proximity Read ↗

Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis.Semantic proximity Read ↗

Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid.Semantic proximity Read ↗

Complex expression patterns support potential roles for maternally derived activins in the establishment of pregnancy in mouseSemantic proximity Read ↗

The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development.Semantic proximity Read ↗

Activin C Antagonizes Activin A in Vitro and Overexpression Leads to Pathologies in VivoSemantic proximity Read ↗

Different Immunoregulation Roles of Activin A Compared With TGF-βSemantic proximity Read ↗

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