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Article

Glucocorticoid Repression of AP-1 Is Not Mediated by Competition for Nuclear Coactivators

1 Feb 2001

Abstract excerpt

Interleukin-6 (IL-6) is a pleiotropic cytokine that is involved in many autoimmune and inflammatory diseases. Transcriptional control of IL-6 gene expression is exerted by various compounds, among which glucocorticoids are the most potent antiinflammatory and immunosuppressive agents currently in use. Glucocorticoids exert their transrepressive actions by negatively interfering with transcription factors, such as...

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PMID: 11158329
DOI: 10.1210/mend.15.2.0591

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