Article
Inherited variability of the mitochondrial genome and successful aging in humans.
Annals of the New York Academy of Sciences - 1 Jun 2000
de Benedictis G, Carrieri G, Varcasia O, Bonafè M, Franceschi C
Abstract excerpt
Increasing data indicate that polymorphic variants of nuclear loci can affect rate and quality of aging in humans. However, the mitochondrial genome is another good candidate, because of the central role played by mitochondrial genes in oxidative phosphorylation (OXPHOS) and cell metabolism. A characteristic of the mitochondrial genome (mtDNA) is the high level of interindividual variability that ensues from high...
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