Article
Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism.
The Journal of clinical investigation - 1 Sept 2001
Opitz O G, Suliman Y, Hahn W C, Harada H, Blum H E, Rustgi A K
Abstract excerpt
The immortalization of human cells is a critical step in multistep carcinogenesis. Oral-esophageal carcinomas, a model system to investigate molecular mechanisms underlying squamous carcinogenesis, frequently involve cyclin D1 overexpression and inactivation of the p53 tumor suppressor. Therefore, our goal was to establish the functional role of cyclin D1 overexpression and p53 inactivation in the immortalization...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.