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Article

Immortalization of Primary Keratinocytes and Its Application to Skin Research

27 Aug 2015

Abstract excerpt

As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for the assessment of potential toxicities of various chemicals used in cosmetics. However, its short lifespan in ex vivo setting has been a great hurdle for many practical applications. Therefore, a number of immortalization attempts have...

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PMID: 26336577
DOI: 10.4062/biomolther.2015.038

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