Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699.

The Journal of antibiotics - 1 May 2000

Doi-Katayama Y, Yoon Y J, Choi C Y, Yu T W, Floss H G, Hutchinson C R

Abstract excerpt

The role of two thioesterase genes in the premature release of polyketide synthase intermediates during rifamycin biosynthesis in the Amycolatopsis mediterranei S699 strain was investigated. Creation of an in-frame deletion in the rifR gene led to a 30 approximately 60% decrease in the production of both rifamycin B by the S699 strain or a series of tetra- to decaketide shunt products of polyketide chain assembly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actinomycetales
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Anti-Bacterial Agents

Share to Base Sequence

Share to Esterases

Share to Genes, Bacterial

Share to Multienzyme Complexes

Share to Peptide Chain Elongation, Translational

Source

Identifiers

PMID: 10908112
DOI: 10.7164/antibiotics.53.484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699.PMID 10908112Read ↗

Intermediates of rifamycin polyketide synthase produced by an Amycolatopsis mediterranei mutant with inactivated rifF gene.Semantic proximity Read ↗

RifZ (AMED_0655) Is a Pathway-Specific Regulator for Rifamycin Biosynthesis in Amycolatopsis mediterranei.Semantic proximity Read ↗

Rifamycins: strain improvement program.Semantic proximity Read ↗

Modulation of lipid metabolism and spiramycin biosynthesis in Streptomyces ambofaciens unstable mutants.Semantic proximity Read ↗

Cloning and preliminary characterization of lh3 gene encoding a putative acetyltransferase from a rifamycin SV-producing strain Amycolatopsis mediterranei.Semantic proximity Read ↗

Deciphering the late steps of rifamycin biosynthesis.Semantic proximity Read ↗

Improvement of industry-applied rifamycin B-producing strain, Amycolatopsis mediterranei, by rational screening.Semantic proximity Read ↗

In vivo characterization of tandem C-terminal thioesterase domains in arthrofactin synthetase.Semantic proximity Read ↗

An eukaryotic-type serine/threonine protein kinase involved in the carbon source-dependent pigment biosynthesis in Amycolatopsis mediterranei U32.Semantic proximity Read ↗

Sequence analysis and expression of the aspartokinase and aspartate semialdehyde dehydrogenase operon from rifamycin SV-producing amycolatopsis mediterranei.Semantic proximity Read ↗

Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis.Semantic proximity Read ↗

Interchenar retrotransfer of aureothin intermediates in an iterative polyketide synthase module.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.