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Article

Interchenar retrotransfer of aureothin intermediates in an iterative polyketide synthase module.

Journal of the American Chemical Society - 1 Aug 2012

Busch Benjamin, Ueberschaar Nico, Sugimoto Yuki, Hertweck Christian

Abstract excerpt

The course of the enigmatic iterative use of a polyketide synthase module was deduced from targeted domain inactivation in the aureothin assembly line. Mutational analyses revealed that the N-terminus of AurA is not involved in the iteration process, ruling out an ACP-ACP shuttle. Furthermore, an AurA(KS°, ACP°)-AurA(AT(0)) heterodimer proved to be nonfunctional, whereas aureothin production was restored in a...

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Identifiers

PMID: 22799266
DOI: 10.1021/ja304454r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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