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Article

Modulation of lipid metabolism and spiramycin biosynthesis in Streptomyces ambofaciens unstable mutants.

Applied and environmental microbiology - 1 Jun 1999

Schauner C, Dary A, Lebrihi A, Leblond P, Decaris B, Germain P

Abstract excerpt

Streptomyces ambofaciens is prone to genetic instability involving genomic rearrangements at the extremities of the chromosomal DNA. An amplified DNA sequence (ADS205), including an open reading frame (orfPS), is responsible for the reversible loss of spiramycin production in the mutant strain NSA205 (ADS205(+) Spi-). The product of orfPS is homologous to polyketide synthase systems (PKSs) involved in the...

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Identifiers

PMID: 10347068
DOI: 10.1128/AEM.65.6.2730-2737.1999
PMCID: PMC91403

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