Article
RifZ (AMED_0655) Is a Pathway-Specific Regulator for Rifamycin Biosynthesis in Amycolatopsis mediterranei.
Applied and environmental microbiology - 15 Apr 2017
Li Chen, Liu Xinqiang, Lei Chao, Yan Han, Shao Zhihui, Wang Ying, Zhao Guoping, Wang Jin, Ding Xiaoming
Abstract excerpt
Rifamycin and its derivatives are particularly effective against the pathogenic mycobacteria Mycobacterium tuberculosis and Mycobacterium leprae Although the biosynthetic pathway of rifamycin has been extensively studied in Amycolatopsis mediterranei, little is known about the regulation in rifamycin biosynthesis. Here, an in vivo transposon system was employed to identify genes involved in the regulation of...
Topics
- Actinomycetales
- Bacterial Proteins
- Biosynthetic Pathways
- DNA Transposable Elements
- Gene Expression Regulation, Bacterial
- Gene Knockout Techniques
- Genes, Bacterial
- Homologous Recombination
- Multigene Family
- Mutation
- Open Reading Frames
- Operon
- Promoter Regions, Genetic