Article
Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana.
Current biology : CB - 3 Sept 2002
Kirik Victor, Mathur Jaideep, Grini Paul E, Klinkhammer Irene, Adler Klaus, Bechtold Nicole, Herzog Michel, Bonneville Jean-Marc, Hülskamp Martin
Abstract excerpt
The biogenesis of microtubules comprises several steps, including the correct folding of alpha- and beta-tubulin and heterodimer formation. In vitro studies and the genetic analysis in yeast revealed that, after translation, alpha- and beta-tubulin are processed by several chaperonins and microtubule-folding cofactors (TFCs) to produce assembly-competent alpha-/beta-tubulin heterodimers. One of the TFCs, TFC-C,...
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