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Article

The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II.

Gene - 11 Jul 2000

Lyon C J, Evans C J, Bill B R, Otsuka A J, Aguilera R J

Abstract excerpt

The Caenorhabditis elegans nuc-1 gene has previously been implicated in programmed cell death due to the presence of persistent undegraded apoptotic DNA in nuc-1 mutant animals. In this report, we describe the cloning and characterization of nuc-1, which encodes an acidic nuclease with significant sequence similarity to mammalian DNase II. Database searches performed with human DNase II protein sequence revealed...

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Identifiers

PMID: 10903446
DOI: 10.1016/s0378-1119(00)00213-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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