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Article

One sequence, two ribozymes: implications for the emergence of new ribozyme folds.

Science (New York, N.Y.) - 21 Jul 2000

Schultes E A, Bartel D P

Abstract excerpt

We describe a single RNA sequence that can assume either of two ribozyme folds and catalyze the two respective reactions. The two ribozyme folds share no evolutionary history and are completely different, with no base pairs (and probably no hydrogen bonds) in common. Minor variants of this sequence are highly active for one or the other reaction, and can be accessed from prototype ribozymes through a series of...

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Identifiers

PMID: 10903205
DOI: 10.1126/science.289.5478.448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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