Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease.

Experimental and clinical immunogenetics - 1 Jan 2000

Alper C A, Dubey D P, Yunis E J, Awdeh Z

Abstract excerpt

We wished to determine the frequencies of the MHC and non-MHC susceptibility genes for polygenic autoimmune diseases like type 1 diabetes (IDDM). We used Mendelian inheritance and the Hardy-Weinberg equilibrium to calculate the frequencies of mating pairs and susceptible offspring under classical recessive and dominant inheritance of the MHC susceptibility gene. We then analyzed the distribution of haplotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA Antigens

Share to Major Histocompatibility Complex

Share to Models, Genetic

Share to Multifactorial Inheritance

Share to Multiple Sclerosis

Share to Penetrance

Source

Identifiers

PMID: 10899739
DOI: 10.1159/000019133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease.PMID 10899739Read ↗

Analysis of the threshold liability model provides new understanding of causation in autoimmune diseases.Semantic proximity Read ↗

The MHC, disease and selection.Semantic proximity Read ↗

Good copy, bad copy: choosing animal models for HLA-linked diseases.Semantic proximity Read ↗

[The major histocompatibility complex (MHC) and population genetics].Semantic proximity Read ↗

Estimating the allele frequency of autosomal recessive disorders through mutational records and consanguinity: the Homozygosity Index (HI).Semantic proximity Read ↗

A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8.Semantic proximity Read ↗

Comparison of simple and modified Bernstein's methods in estimation of recessive allele frequency in the HLA system.Semantic proximity Read ↗

Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles.Semantic proximity Read ↗

The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium.Semantic proximity Read ↗

Non-random mating, parent-of-origin, and maternal-fetal incompatibility effects in schizophrenia.Semantic proximity Read ↗

HLA class II polymorphism and genetic susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.