Article
Comparison of simple and modified Bernstein's methods in estimation of recessive allele frequency in the HLA system.
Annals of human genetics - 1 Jan 1990
Nam J M
Abstract excerpt
Bias and inefficiency of Bernstein's estimator of the recessive allele frequency in generalized ABO-like systems are important for situations where the frequency is small and the number of codominant alleles is large. A modified Bernstein's estimator of the recessive (Smith, 1967) has much smaller bias and higher efficiency than Bernstein's for large samples. Analogous findings are generally observed for small...
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