Article
Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred.
Genetic epidemiology - 1 Jan 1991
Rigby A S, Silman A J, Voelm L, Gregory J C, Ollier W E, Khan M A, Nepom G T, Thomson G
Abstract excerpt
We examined the mode of inheritance of rheumatoid arthritis (RA) and estimated the genetic contribution of the HLA-linked locus to the development of RA using data from 111 multiplex families (54 London, 57 Cleveland), and 43 randomly ascertained patients (Seattle). HLA-DR4 was present in 78 multiplex probands (70%); a further 16 probands who were negative for DR4 were positive for DR1. Both DR4 and DR1 were...
Topics
- Adult
- Alleles
- Arthritis, Rheumatoid
- Epidemiologic Methods
- Epitopes
- Genes, Dominant
- Genes, Recessive
- Genetic Linkage
- HLA-DR Antigens
- Haplotypes
- Humans