Article
Nickel(II) induces microsatellite mutations in human lung cancer cell lines.
Mutation research - 20 Jul 2000
Zienolddiny S, Svendsrud D H, Ryberg D, Mikalsen A B, Haugen A
Abstract excerpt
Nickel(II) is a human carcinogen causing respiratory cancers. The purpose of this study was to determine whether Ni(II) may induce microsatellite mutations in human cells. We transfected the three human lung tumor cell lines A427, HCC15 and NCI-H2009 with a mammalian expression vector containing a (CA)(13) repeat in the coding sequences of the reporter hygromycin gene (hyg). A total of 33 clones carrying the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.