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Nickel accumulation in lung tissues is associated with increased risk of p53 mutation in lung cancer patients.

Environmental and molecular mutagenesis - 1 Oct 2014

Chiou Yu-Hu, Wong Ruey-Hong, Chao Mu-Rong, Chen Chih-Yi, Liou Saou-Hsing, Lee Huei

Abstract excerpt

Occupational exposure to nickel compounds has been associated with lung cancer. The correlation between high nickel levels and increased risk of lung cancer has been previously reported in a case-control study. This study assessed whether nickel exposure increased the occurrence of p53 mutations due to DNA repair inhibition by nickel. A total of 189 lung cancer patients were enrolled to determine nickel levels in...

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Identifiers

PMID: 24711049
DOI: 10.1002/em.21867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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