Article
Characterization of a nickel resistant mouse cell line.
Biological trace element research - 1 Jan 2000
Imbra R J, Wang X W, Costa M
Abstract excerpt
Nickel is a potent carcinogen and, at high concentrations, is toxic to mammalian cells. The effects associated with nickel exposure are well-documented but its mechanism of action in the cell has not yet been fully described. In order to understand the metabolic fate of nickel in mammalian cells, a variant cell population has been selected that continues to grow and divide in the presence of nickel chloride...
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