Article
Nickel mutagenesis: alteration of the MuSVts110 thermosensitive splicing phenotype by a nickel-induced duplication of the 3' splice site.
Molecular carcinogenesis - 1 Jan 1991
Chiocca S M, Sterner D A, Biggart N W, Murphy E C
Abstract excerpt
We investigated DNA damage caused by carcinogenic metals in a murine sarcoma virus (MuSV)-based mutagenicity assay in which mutations targeted to v-mos expression can be selected. Nickel chloride treatment of NRK cells (termed 6m2 cells) infected with MuSVts110, a retrovirus conditionally defecti...
Topics
- Animals
- Cadmium
- Chromium
- Chromosome Deletion
- DNA Damage
- DNA, Viral
- Gene Expression Regulation, Viral
- Mutagenicity Tests
- Nickel
- Phenotype
- Sarcoma Viruses, Murine
- Sarcoma, Experimental
- Temperature
- Transfection