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Article

Double mutations in klotho and osteoprotegerin gene loci rescued osteopetrotic phenotype.

Endocrinology - 1 Dec 2002

Yamashita Teruhito, Okada Seiji, Higashio Kanji, Nabeshima Yo-Ichi, Noda Masaki

Abstract excerpt

Klotho gene mutant mice (klotho mice, also called kl/kl) exhibit osteopetrosis in the metaphysis of femora and tibiae and die within 3 months. We previously showed by semiquantitative RT-PCR that osteoprotegerin (opg) expression levels in klotho mice were about 2-fold higher than those in wild-ty...

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Identifiers

PMID: 12446599
DOI: 10.1210/en.2002-220602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12446599-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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