Double mutations in klotho and osteoprotegerin gene loci rescued osteopetrotic phenotype.

Abstract excerpt

Klotho gene mutant mice (klotho mice, also called kl/kl) exhibit osteopetrosis in the metaphysis of femora and tibiae and die within 3 months. We previously showed by semiquantitative RT-PCR that osteoprotegerin (opg) expression levels in klotho mice were about 2-fold higher than those in wild-type mice in the bone marrow, spleen, and lung. To examine whether the high osteoprotegerin expression levels account for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Femur
• Share to Glucuronidase
• Share to Hematopoiesis