Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2001

Nakagawa H, Chadwick R B, Peltomaki P, Plass C, Nakamura Y, de La Chapelle A

Abstract excerpt

We hypothesize that loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene is associated with a predisposition to sporadic colorectal cancer. We confirmed a previously known strong correlation between LOI and microsatellite instability and showed that LOI was not a consequence of microsatellite instability or mismatch repair deficiency. LOI of IGF2 correlated strongly with biallelic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to CCCTC-Binding Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to Genes, p16

Share to Insulin-Like Growth Factor II

Share to MutL Protein Homolog 1

Share to RNA, Untranslated

Source

Open in PubMed Open full text

Identifiers

PMID: 11120891
DOI: 10.1073/pnas.98.2.591
PMCID: PMC14632

Genes

IGF2
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer.PMID 11120891Read ↗

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients.Semantic proximity Read ↗

Examination of IGF2 and H19 loss of imprinting in bladder cancer.Semantic proximity Read ↗

Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer.Semantic proximity Read ↗

High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas. Uncoupling of H19 and IGF2 expression and biallelic hypomethylation of H19.Semantic proximity Read ↗

Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions.Semantic proximity Read ↗

Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.Semantic proximity Read ↗

Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.Semantic proximity Read ↗

Restoration of IGF2 imprinting by polycomb repressive complex 2 docking factor SUZ12 in colon cancer cells.Semantic proximity Read ↗

Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastomaSemantic proximity Read ↗

Loss of imprinting and overexpression of IGF2 gene in gastric adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.