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Article

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.

Science (New York, N.Y.) - 14 Mar 2003

Cui Hengmi, Cruz-Correa Marcia, Giardiello Francis M, Hutcheon David F, Kafonek David R, Brandenburg Sheri, Wu Yiqian, He Xiaobing, Powe Neil R, Feinberg Andrew P

Abstract excerpt

Loss of imprinting (LOI), an epigenetic alteration affecting the insulin-like growth factor II gene (IGF2), is found in normal colonic mucosa of about 30% of colorectal cancer (CRC) patients, but it is found in only 10% of healthy individuals. In a pilot study to investigate the utility of LOI as a marker of CRC risk, we evaluated 172 patients at a colonoscopy clinic. The adjusted odds ratio for LOI in...

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Source

Identifiers

PMID: 12637750
DOI: 10.1126/science.1080902

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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