Article
Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1.
Journal of virology - 1 Aug 2000
Kuhmann S E, Platt E J, Kozak S L, Kabat D
Abstract excerpt
In addition to the primary cell surface receptor CD4, CCR5 or another coreceptor is necessary for infections by human immunodeficiency virus type 1 (HIV-1), yet the mechanisms of coreceptor function and their stoichiometries in the infection pathway remain substantially unknown. To address these issues, we studied the effects of CCR5 concentrations on HIV-1 infections using wild-type CCR5 and two attenuated...
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