Article
Concordant utilization of macrophage entry coreceptors by related variants within an HIV type 1 primary isolate viral swarm.
AIDS research and human retroviruses - 1 Jul 2001
Singh A, Yi Y, Isaacs S N, Kolson D L, Collman R G
Abstract excerpt
There is considerable diversity among HIV-1 strains in terms of their ability to use entry coreceptors on macrophages, especially CXCR4, but it is not known whether virus-specific differences exist among related members of a viral swarm. Defining how entry coreceptors on primary target cells are utilized by the spectrum of HIV-1 variants that emerge in vivo is important for understanding the relationship between...
Topics
- Cell Line
- Gene Products, env
- Genetic Variation
- HIV-1
- Humans
- Macrophages
- Membrane Fusion
- Receptors, CCR5
- Receptors, CXCR4