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Article

Contrasting use of CCR5 structural determinants by R5 and R5X4 variants within a human immunodeficiency virus type 1 primary isolate quasispecies.

Journal of virology - 1 Nov 2003

Yi Yanjie, Singh Anjali, Shaheen Farida, Louden Andrew, Lee ChuHee, Collman Ronald G

Abstract excerpt

Macrophagetropic R5 human immunodeficiency virus type 1 (HIV-1) isolates often evolve into dualtropic R5X4 variants during disease progression. The structural basis for CCR5 coreceptor function has been studied in a limited number of prototype strains and suggests that R5 and R5X4 Envs interact differently with CCR5. However, differences between unrelated viruses may reflect strain-specific factors and do not...

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Share to CXCR2 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CCR5

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Source

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Identifiers

PMID: 14581542
DOI: 10.1128/jvi.77.22.12057-12066.2003
PMCID: PMC254272

Genes

CCR5
CXCR4
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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